Effects of Statins on the Serum Uric acid of Dyslipidemic Patients in the University of Port-Harcourt Teaching Hospital
Keywords:
Port-Harcourt, Dyslipidemia, statins, Uric acidAbstract
Introduction: Uric acid, which is an end product of purine metabolism is associated with cardiovascular risk via its up regulation of inflammatory markers.
Objectives: To determine the effects of different statins on the serum uric acid level of dyslipidemic patients in the University of Port-Harcourt Teaching Hospital, as well as correlate the doses of the selected statins with these effects.
Method: This was a cohort study carried out over a period of 9 months from June 2017 to February 2018, in the University of Port-Harcourt Teaching Hospital. Dyslipidemic subjects who met the study criteria, had their baseline serum uric acid assayed and repeated at 3months.
Results: Three hundred and sixty six subjects were recruited, but forty-six were lost to follow-up. The subjects used for final analysis were 160 test subjects placed on statins and 160 control subjects who were statin- free. The mean age± SD of the test subjects was 57.02±12.45, while that of the control subjects was 51.86±13.27. Statins had a significant effect on the reduction of serum uric acid, although there was no significant correlation between the doses of statins used and the uric acid levels.
Conclusions: Statins were found to have hypouricemic effects, although there was no significant correlation between the dosages of statins and their effects on serum uric acid.
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References
1. Jin M, Yang F, Yang I, Yin Y, Luo JJ, Wang H, et al. Uric acid, hyperuricemia and vascular diseases. Frontiers in bioscience: a journal and virtual library. 2012;17: 656-659
2. Rodriguez C.J, Daviglus M.L, Swett K, González H.M, Gallo L.C., Wassertheil-Smoller, S et al. Dyslipidemia patterns among Hispanics/Latinos of diverse background in the United States. The American journal of medicine. 2014; 127:1186-1194
3. Mukherji S, Ramakrishnan TS. World Heart Day: May the force be with your HEART. Medical journal, Armed Forces India. 2016;4:313.
4. Lu W, Xu Y, Shao X, Gao F, Li Y, Hu J. Uricacid produces an inflammatory response through activation of NF-κB in the hypothalamus: implications for the pathogenesis of metabolic disorders. Scientific reports.
2015;16:121-144.
5. Rohilla A, Rohilla S, Kumar A, Khan MU, Deep A. Pleiotropic effects of statins: A boulevard to cardioprotection. Arabian Journal of Chemistry. 2016 ;9:S21-7
6. Shuhaili MF, Samsudin IN, Stanslas J, Hasan S, Thambiah SC. Effects of different types of statins on lipid profile: a perspective on Asians. NDJMS Vol.2 Issue 2, December 2019 International journal of
endocrinology and metabolism. 2017;15(2).
7. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel
III). JAMA 2001;285:2486-2487.
8. Vassault A, Grafmeyer D, De Graeve J, Cohen R, Beaudonnet A, Bienvenu J. Quality specifications and allowable limits for validation of methods used in clinical biochemistry. In Annal esde biologie Clinique.1999;57:685-695.
9. Fossati P, PrencipeL. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clinical chemistry, 1982;28: 2077-2080.
10. Zhao Y, Yang X, Lu W, Liao H, Liao F. Uricase based methods for determination of uric acid in serum. Microchimica Acta. 2009;164: 1-6.
11. Ogata N, Fujimori S, Oka Y, Kaneko K. Effects of three strong statins (atorvastatin, pitavastatin, and rosuvastatin) on serum uric acid levels in dyslipidemic patients. Nucleosides, nucleotides and nucleic
acids. 2010 ; 29: 321-324.
12. Milionis HJ, Kakafika AI, Tsouli SG, Athyros VG., Bairaktari ET, Seferiadis KI et al. Effects of statin treatment on uric acid homeostasis in patients with primary hyperlipidemia. American heart journal. 2004; 148: 635 - 640.
13. Derosa G, Maffioli P, Reiner Ž, Simental-Mendía LE, Sahebkar A. Impact of statin therapy on plasma uricacid concentrations: a systematic review and meta-analysis. Drugs. 2016;76:947-56
14. Clark M., Finkel R., Rey J., Whalen K Lippincott's Illustrated Reviews: Pharmacology. Lippincott Williams and Wilkins, Baltimore. 2012; 5th Edition., pp 455-56
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